CD252 (OX40L) antibodies – functional grade, mouse

CD252 (OX40L) antibodies – functional grade, mouse

Clone: RM134L
Clone RM134L recognizes CD252 (OX40L), a ligand of OX40 receptor, belonging to the TNF superfamily. Expression of CD252 can be induced on B cells, dendritic cells, macrophages, mast cells, natural killer (NK) cells, endothelial cells, and smooth muscle cells. Expression of the cognate receptor OX40 is found on activated CD4 cells, CD8 cells, regulatory T cells, NKT cells, NK cells, and neutrophils, but the function of OX40 signaling is extensively studied only in T cells. CD252 (OX40L)-OX40 interaction promotes the proliferation and surival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells (nTreg), and inhibits the generation of inducible Treg cells.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative names

TNFSF4, Ath-1, Ath1, CD134L, OX40L, Txgp1, Txgp1l, gp34

Technical specifications

  • Antigen: CD252 (OX40L)
  • Clone: RM134L
  • Isotype: rat IgG2bκ
  • Alternative names of antigen: TNFSF4, Ath-1, Ath1, CD134L, OX40L, Txgp1, Txgp1l, gp34
  • Entrez Gene ID: 22164
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, heart, leukemia cells, mast cells, monocytes, spleen, T cells, thymocytes
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
  • Selected references

    1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
    2. Croft, M. et al. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1): 173-191
    3. Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98
Product options: 1
500 µg in 0.5 mL
EUR 355,00 

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