CD25 antibodies, human

CD25 antibodies, human

Clone: 4E3 | Dilution: 1:50
The CD25 antibody recognizes the human CD25 antigen, a 28 kDa glycoprotein, also known as the low-affinity interleukin-2 receptor alpha chain (IL-2Rα). CD25 is expressed on activated T and B cells, on macrophages, and on a subset of non-activated CD4
+
regulatory T cells.
The CD25 antigen contains three epitope regions called A, B, and C. This CD25 antibody recognizes epitope region B.

Alternative names

IL2RA, IDDM10, IL2R, TCGFR, p55, Tac, IL-2Rα

Technical specifications

  • Antigen: CD25
  • Clone: 4E3
  • Isotype: mouse IgG2bκ
  • Isotype control: Mouse IgG2b – isotype control antibodies
  • Alternative names of antigen: IL2RA, IDDM10, IL2R, TCGFR, p55, Tac, IL-2Rα
  • Entrez Gene ID: 3559
  • Molecular mass of antigen [kDa]: 28
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, basophils, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, osteoblasts, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164
    2. Lamprecht, B. et al. (2008) Aberrant expression of the Tʜ2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood 112(8): 3339-3347
    3. Maloy, K. J. et al. (2001) Regulatory T cells in the control of immune pathology. Nat. Immunol. 2(9): 816-822
    4. Shevach, E. M. (2001)
      Certified professionals: CD4
      +
      CD25
      +
      suppressor T cells.
      J. Exp. Med. 193(11): F41-F46
    5. Chaput, N. et al. (2013)
      Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR
      +
      NK cell levels correlate with disease outcome.
      Oncoimmunology 2(2): e23080
Product options: 8
130-113-845

CD25-VioBright FITC, human

for 30
tests
(1)
EUR 130,00 
130-113-283

CD25-VioBright FITC, human

for 100
tests
(1)
EUR 310,00 
130-113-844

CD25-PE, human

for 30
tests
(1)
EUR 105,00 
130-113-282

CD25-PE, human

for 100
tests
(1)
EUR 255,00 
130-113-842

CD25-APC, human

for 30
tests
(1)
EUR 105,00 
130-113-280

CD25-APC, human

for 100
tests
(1)
EUR 255,00 
130-113-843

CD25-Biotin, human

for 30
tests
(1)
EUR 80,00 
130-113-281

CD25-Biotin, human

for 100
tests
(1)
EUR 190,00 

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