CD230 (PrP) antibodies, human

CD230 (PrP) antibodies, human

Clone: REA203 | Dilution: 1:11
Clone REA203 recognizes CD230, commonly known as the prion protein (PrP). The normal cellular PrP (PrP
c
) is a ubiquitously expressed glycosylphosphatidyl-inositol (GPI) anchored protein. Though the main function of PrP
c
remains unknown, it has been suggested that PrP
c
may play a role in copper regulation, antioxidant activity, intracellular signaling. PrP
sc
is the conformational isoform of PrP
c
with similar primary sequence but different tertiary structure and is associated with neurodegenerative diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy, and scrapie in sheeps. PrP
sc
is suggested to derive from PrP
c
in a posttranslational process which involves PrP
c
-PrP
sc
molecular interactions.
Additional information: Clone REA203 displays negligible binding to Fc receptors.

Alternative names

PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30

Technical specifications

  • Antigen: CD230 (PrP)
  • Clone: REA203
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30
  • Distribution of antigen: brain
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Maas, E. et al. (2007) Scrapie infection of Prion protein-deficient cell line upon ectopic expression of mutant Prion proteins. J. Biol. Chem. 282: 18702-18710
    2. Basu, S. et al. (2007) Modulation of proteinase K-resistant Prion protein in cells and infectious brain homogenate by redox iron: Implications for prion replication and disease pathogenesis. Mol. Cell. Biol. 18: 3302-3312
Product options: 8
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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