Anti-Rae-1α/β/γ antibodies, mouse

Anti-Rae-1α/β/γ antibodies, mouse

Clone: REA578 | Dilution: 1:10
Clone REA578 recognizes the Rae-1α/β/γ antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1α/β/γ were detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells
in vivo
. Clone REA578 does not detect Rae-1δ/ε.
Additional information: Clone REA578 displays negligible binding to Fc receptors.

Alternative names

Mrnp41

Technical specifications

  • Antigen: Rae-1α/β/γ
  • Clone: REA578
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Mrnp41
  • Entrez Gene ID: 19368, 19369, 19370
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nomura, M. et al. (1996) Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biol. Chem. 120(5): 987-995
    2. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
    3. Diefenbach, A. et al. (2001) Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413(6852): 165-171
Product options: 10
9 µg in 300 µL (1)
EUR 40,00 
30 µg in 1 mL (1)
EUR 100,00 
9 µg in 300 µL (1)
EUR 58,00 
30 µg in 1 mL (1)
EUR 100,00 
9 µg in 300 µL (1)
EUR 71,00 
30 µg in 1 mL (1)
EUR 110,00 
9 µg in 300 µL (1)
EUR 76,00 
30 µg in 1 mL (1)
EUR 110,00 
9 µg in 300 µL (1)
EUR 22,00 
30 µg in 1 mL (1)
EUR 60,00 

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