Anti-IRF-7 antibodies, human

Anti-IRF-7 antibodies, human

Clone: REA521 | Dilution: 1:11
Clone REA521 recognizes the human interferon regulatory factor 7 (IRF-7) antigen, regardless of phosphorylation status. IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes.
Additional information: Clone REA521 displays negligible binding to Fc receptors.

Alternative names

IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C

Technical specifications

  • Antigen: IRF-7
  • Clone: REA521
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C
  • Entrez Gene ID: 3665
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: dendritic cells, lymphocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Zhang L. et al. (1997) IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol. Cell. Biol. 17(10): 5748-5757
    2. Smith, E. J. et al. (2001) IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J. Biol. Chem. 276(12): 8951-8957
    3. Sgarbanti, M. et al. (2007) IRF-7: new role in the regulation of genes involved in adaptive immunity. Ann. N. Y. Acad. Sci. 1095: 325-333
Product options: 6
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 

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