Anti-Bcl-2 antibodies, human

Anti-Bcl-2 antibodies, human

Clone: REA872 | Dilution: 1:50
Clone REA872 recognizes the human Bcl-2 antigen, which is an intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is a member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor.
Additional information: Clone REA872 displays negligible binding to Fc receptors.

Alternative names

BCL2

Technical specifications

  • Antigen: Bcl-2
  • Clone: REA872
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: BCL2
  • Entrez Gene ID: 596
  • Molecular mass of antigen [kDa]: 26
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Bruey, J. M. et al. (2007) Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129(1): 45-56
    2. Wei, Y. et al. (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30(6): 678-688
Product options: 6
130-114-337

Anti-Bcl-2-FITC, human

for 30
tests
(1)
EUR 100,00 
130-114-230

Anti-Bcl-2-FITC, human

for 100
tests
(1)
EUR 240,00 
130-114-338

Anti-Bcl-2-PE, human

for 30
tests
(1)
EUR 115,00 
130-114-231

Anti-Bcl-2-PE, human

for 100
tests
(1)
EUR 285,00 
130-114-339

Anti-Bcl-2-APC, human

for 30
tests
(1)
EUR 115,00 
130-114-232

Anti-Bcl-2-APC, human

for 100
tests
(1)
EUR 285,00 

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