Human Noggin

Human Noggin

Human Noggin is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.


Human Noggin can be used for a variety of applications, including:
  • ES/ iPS differentiation into neural stem cells and retinal cells.
  • Differentiation of human ES and iPS cell-derived endodermal lineages.
  • Induction of adipogenic differentiation of MSCs.

Background information

Noggin is a disulfide-linked homodimer that acts by binding members of the TGF-β family, and consequently blocks their ability to signal through their receptors. Noggin plays a crucial role in regulating developmental processes by inhibiting the signaling pathway of bone morphogenetic protein 4 (BMP-4), as well as other BMPs. During embryogenesis Noggin is produced by the dorsal mesoderm and is important for the correct bone morphology and neural tissue formation. Mutations in the Noggin-coding gene (NOG) are associated with several bone diseases. The sequence of Noggin protein shows high homology across several species.

Quality description

cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Inhibition of BMP-4–induced alkaline phosphatase production
  • research grade: ≥ 3.3×
Product options: 4

Human Noggin, research grade

HEK293 cells
5 µg
EUR 55,00 

Human Noggin, research grade

HEK293 cells
20 µg
EUR 190,00 

Human Noggin, research grade

HEK293 cells
100 µg
EUR 630,00 

Human Noggin, research grade

HEK293 cells
1000 µg
EUR 3.365,00 

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