CD62L, also known as L-Selectin, LECAM-1, or LAM1, is a cell adhesion molecule on lymphocytes and belongs to the selectin family of proteins
. It recognizes sialylated carbohydrate groups and is continuously cleaved from the cell surface by ADAM17. CD62L acts as a homing receptor for lymphocytes to enter secondary lymphoid tissues via high endothelial venules and is commonly found on the cell surface of T cells. Naive T cells and central memory T cells express CD62L to localize in secondary lymphoid organs.
CD62L is continuously endoproteolytically cleaved from the cell surface of CD62L-expressing neutrophils and lymphocytes (shedding). Proteolysis is accelerated, e.g., after antigen activation of T cells
In clinical trials, a CD62L
phenotype of T cells engineered with