CD71 Antibody, anti-human
Clone:
AC102
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2a, mouse IgG2aκ
Applications:
MC, FC, MICS, IF, IHC
Alternative names:
TFRC, T9, TfR, TfR1, TR, Trfr, p90

Extended validation for CD71 Antibody, anti-human

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with AC102
REAL444+
CY1G4+
OKT9++
M-A712++
T56/14+
MEM-75-
REA902++
Cells were incubated with an excess of purified unconjugated CD71 (AC102) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD71 Antibody, anti-human

Overview

The CD71 antibody recognizes the transferrin receptor, which is essential for iron transport into proliferating cells. CD71 is expressed on marrow stromal cells (MSCs) from bone marrow, on activated T and B lymphocytes, macrophages, and all proliferating cells. It is upregulated on lymphocytes during proliferative responses to antigens or mitogens but is not expressed on resting lymphocytes. CD71 is present on reticulocytes and erythroid progenitors in fetal liver, cord blood, and peripheral blood, yet it is lost as these differentiate to mature erythrocytes.

Alternative names

TFRC, T9, TfR, TfR1, TR, Trfr, p90

Detailed product information

Technical specifications

CloneAC102
Clonalitymonoclonal
Isotypemouse IgG2aκ, mouse IgG2a
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD71
Alternative names of antigenTFRC, T9, TfR, TfR1, TR, Trfr, p90
Molecular mass of antigen [kDa]85
Distribution of antigenendothelial cells, NK cells, ILC, mesenchymal stem cells, ES and iPS cells, brain
Entrez Gene ID7037
RRIDAB_2857661, AB_2857636, AB_2928556, AB_2928555, AB_2660539, AB_2660540, AB_2660541, AB_615104, AB_2660545, AB_2660546, AB_2660549, AB_2660550, AB_2928558, AB_2928557, AB_2660551

Resources for CD71 Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD71 Antibody, anti-human

Publications

  1. Loken, M. R. et al. (1987) Flow cytometric analysis of human bone marrow: I. Normal erythroid development. Blood 69: 255-263
  2. Judd, W. et al. (1980) Novel surface antigen expressed on dividing cells but absent from nondividing cells. J. Exp. Med. 152: 1430-1435
  3. Phillips, J. H. et al. (1984) Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens. J. Exp. Med. 159: 993-1008
  4. Pittenger, M. F. et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147

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