Exosomes belong to the group of extracellular vesicles (EV) and play a key role in cellular functions. Consequently, they are of great interest in basic research, as well as in future diagnostic applications and/or clinical settings. Our specific solutions enable you to carry out exosome isolation without any density gradient centrifugation. It is possible to target CD9, CD63, CD81, or all markers combined. On top, we offer a flow cytometry assay for fast exosome screening.
Exosomes belong the to group of extracellular vesicles (EV) and play a key role in cellular functions. Consequently, they are of great interest in basic research as well as in future diagnostic applications or clinical settings. We offer a reliable isolation method that safes time, capital equipment, and high starting volumes (50–100 mL) – a true alternative for conventional ultracentrifugation.
Using our Exosome Isolation Kit, enrichment of EVs has never been easier.
Subpopulations of EVs can be separated using superparamagnetic MACS® MicroBeads. For example, NK cell EVs and platelet EVs can be separated using CD81+ and CD9+ MicroBeads.
For further downstream analysis of exosomes we have established the MACSPlex Exosome Assay. This multiplex bead-based assay consists of capture and detection antibodies to analyze the composition of exosome surface proteins in a given sample by flow cytometry.
Comprehensive – Fast and easy screening of 39 surface markers on EVs
Flexible – Additional antibodies can be added for multi-parameter analysis
EVs isolated from cancer cell lines can be discriminated by differing markers from tumor entities. EVs from melanoma cell line for instance show different surface markers then EVs from colon cancer cells as demonstrated by binding to the respective MACSPlex Exosome capture beads.
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