CD99 antibodies, human

CD99 antibodies, human

Clone: REA1174 | Dilution: 1:50
Clone REA1174 recognizes the human CD99 antigen, a 32 kDa type I single-chain transmembrane sialoglycoprotein which is also known as E2 antigen or MIC2. The expression level of CD99 is particularly high in thymocytes, T cells, T cell leukemias and lymphomas, subsets of mature plasma cells in the medullary cord of reactive lymph nodes, pancreatic islet cells, granulosa cells of the ovary, Sertoli cells of the testes, but absent on granulocytes. It is involved in T cell–adhesion processes and in spontaneous rosette formation with erythrocytes. CD99 plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane and it acts at the same site as, but independently of, PECAM1.
Clone REA1174 displays negligible binding to Fc receptors.

Alternative names

HBA71, MIC2, MIC2X, MIC2Y, MSK5X, E2

Technical specifications

  • Antigen: CD99
  • Clone: REA1174
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HBA71, MIC2, MIC2X, MIC2Y, MSK5X, E2
  • Entrez Gene ID: 4267
  • Molecular mass of antigen [kDa]: 19
  • Distribution of antigen: T cells, thymocytes, plasma cells, leukemia cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBright 515
  • Selected references

    1. Schenkel, A. R. et al. (2002) CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat. Immunol. 3(2): 143-150
    2. Gelin, C. et al. (1989) The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. EMBO J. 8(11): 3253-3259
    3. Edlund, K. et al. (2012) CD99 is a novel prognostic stromal marker in non-small cell lung cancer. Int. J. Cancer 131(10): 2264-2273
Product options: 6
130-121-085

CD99-PE, human

for 30
tests
(1)
EUR 90.00
130-121-078

CD99-PE, human

for 100
tests
(1)
EUR 220.00
130-121-086

CD99-APC, human

for 30
tests
(1)
EUR 90.00
130-121-079

CD99-APC, human

for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 125.00
for 100
tests
(1)
EUR 300.00

Related products

3 products available