CD85h (ILT1) antibodies, human

CD85h (ILT1) antibodies, human

Clone: REA219 | Dilution: 1:11
Clone REA219 recognizes CD85h (ILT1), a member of the immunoglobulin-like transcripts (ILT) family of proteins. ILT family members compose of both activating and inhibitory receptors, where CD85h serves as an activating receptor. In contrast to inhibitory members, CD85h posesses a positively charged amino acid in its trasmembrane domain and a short cytoplasmic domain which is devoid of sequence motifs involved in signal transduction. To transduce activating signal, ILT1 forms a multiprotein complex with FCεRIγ. Expression of ILT1 is found on the surface of monocytes/macrophages, dendritic cells, and on a small subset of NK cells.
Additional information: Clone REA219 displays negligible binding to Fc receptors.

Alternative names

LILRA2, ILT1, LIR-7

Technical specifications

  • Antigen: CD85h (ILT1)
  • Clone: REA219
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRA2, ILT1, LIR-7
  • Distribution of antigen: macrophages, monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nakajima, H. et al. (1999) Cutting edge: human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain. J. Immunol. 162: 5-8
    2. Chen, Y. et al. (2009) Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J. Mol. Biol. 386(3): 841-853
Product options: 12
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EUR 220.00
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EUR 90.00
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EUR 220.00
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tests
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EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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