CD70 antibodies, human

CD70 antibodies, human

Clone: REA292 | Dilution: 1:11
Clone REA292 recognizes the human CD70 antigen, a 50 kDa type II transmembrane glycoprotein also known as CD27 ligand (CD27L) or tumor necrosis factor ligand superfamily member 7 (TNFSF7). CD70 is a member of the TNF superfamily and is expressed by activated mouse T, B, and NK lymphocytes, activated plasmacytoid dendritic cells (pDCs), chronic B cell lymphocytic leukemia, and large B cell lymphomas. It interacts with CD27, its ligand on T cells, in order to promote T-B cell cross-stimulation and co-stimulates B cell proliferation and immunoglobulin production. It also plays a role in the pDC-induced B cell differentiation.
Additional information: Clone REA292 displays negligible binding to Fc receptors.

Alternative names

CD27L, CD27LG, TNFSF7

Technical specifications

  • Antigen: CD70
  • Clone: REA292
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD27L, CD27LG, TNFSF7
  • Entrez Gene ID: 970
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: T cells, B cells, NK cells, dendritic cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Bowman, M. R. et al. (1994) The cloning of CD70 and its identification as the ligand for CD27. J. Immunol. 152(4): 1756-1761
    2. Goodwin, R. G. et al. (1993) Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell 73(3): 447-456
Product options: 12
130-104-356

CD70-FITC, human

for 30
tests
(1)
EUR 75.00
130-104-307

CD70-FITC, human

for 100
tests
(1)
EUR 185.00
130-104-358

CD70-APC, human

for 30
tests
(1)
EUR 90.00
130-104-309

CD70-APC, human

for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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