CD56 antibodies, human

CD56 antibodies, human

Clone: AF12-7H3 | Dilution: 1:11
Clone AF12-7H3 recognizes the human CD56 antigen, a glycoprotein of the Ig-superfamily also known as neural cell adhesion molecule (NCAM), which is expressed in blood on practically all resting and activated NK cells and on a minor subset of CD3
+
T cells. CD56 is reported to be expressed on rhesus monkey monocytes but not on NK cells.
CD56 is also expressed in brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal-derived tumors, myelomas, and myeloid leukemias also express CD56.
The monoclonal antibody AF12-7H3 recognizes an epitope distinct from those recognized by the CD56-specific monoclonal antibodies NCAM16.2 and B159.

Alternative names

NCAM1, MSK39, NCAM, Leu-19, NKH-1

Technical specifications

  • Antigen: CD56
  • Clone: AF12-7H3
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: NCAM1, MSK39, NCAM, Leu-19, NKH-1
  • Entrez Gene ID: 4684
  • Molecular mass of antigen [kDa]: 92
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: brain, cardiac muscle, leukemia cells, liver, lung, NK cells, ES and iPS cells, skeletal muscle, smooth muscle, spleen, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure, PE-Vio770
  • Selected references

    1. Carter, D. L. et al. (1999)
      CD56 identifies monocytes and not natural killer cells in
      Rhesus macaques
      .
      Cytometry 37: 41-50
    2. Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice. PLoS One 6(3): e17454
    3. Stockholm, D. et al. (2011) Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour. PLoS One 5(12): e14441
Product options: 1
130-090-955

CD56 pure, human

50 µg in 1 mL
EUR 81.00