CD222 antibodies, human

CD222 antibodies, human

Clone: REA187 | Dilution: 1:10
Clone REA187 recognizes CD222, a 300 kDa type I transmembrane protein, which serves as a multifunction receptor and is ubiquitously expressed. CD222 has a large extracytoplasmic domain, a single transmembrane region, and a short cytoplasmic tail that lacks intrinsic catalytic activity. The receptor cycles continuously between intracellular compartments and the plasma membrane. At steady state, CD222 is found mainly intracellularly, and to a lesser extent on the cell surface. CD222 binds IGF-2 and mannose-6 phosphate containing ligands such as transforming growth factor‐β, leukemia inhibitory factor, and proliferin. This interaction allows CD222-mediated regulation of ligand dependent signaling and uptake and cellular processing of ligands. CD222 is further suggested to function as the cation-independent cell surface receptor for heparanase. Interaction of heparanase with various cell surfaces is suggested to be important for heparanse functions. Cell surface displayed heparanase allows efficient degaradation of local extracellular matrix (ECM)/basement membrane (BM) components.
Additional information: Clone REA187 displays negligible binding to Fc receptors.

Alternative names

IGF2R, CIMPR, M6P-R, MPR1, MPRI

Technical specifications

  • Antigen: CD222
  • Clone: REA187
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IGF2R, CIMPR, M6P-R, MPR1, MPRI
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, T cells, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Leksa, V. et al. (2012) Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells. J. Biol. Chem. 287: 22450-22462
    2. Wood, R. J. et al. (2008) Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation. J. Biol. Chem. 283: 4165-4176
Product options: 14
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00
130-100-868

CD222-PE, human

for 30
tests
(1)
EUR 90.00
130-100-866

CD222-PE, human

for 100
tests
(1)
EUR 220.00
130-100-863

CD222-APC, human

for 30
tests
(1)
EUR 90.00
130-100-860

CD222-APC, human

for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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