CD21 antibodies, human

CD21 antibodies, human

Clone: REA940 | Dilution: 1:50
Clone REA940 recognizes the human CD21 antigen, a type I membrane glycoprotein. Expression of CD21 in humans is found on B cells, follicular dendritic cells, subsets of epithelial cells, and thymic T cells. The primary function attributed to CD21 has been to amplify the B cell receptor (BCR)–mediated signal transduction in response to antigen recognition. To enhance the BCR mediated activation, CD21 associates with CD19 and CD81 in a B cell–specific signal transduction complex, where interaction of BCR with CR2/CD19 amplifies the signals. In addition, CD21 serves as a receptor for split products of complement protein C3, the gp350/220 viral coat protein of the EBV and the immunoregulatory protein CD23.
Additional information: Clone REA940 displays negligible binding to Fc receptors.

Alternative names

CR2, C3dR, CR, CVID7, SLEB9

Technical specifications

  • Antigen: CD21
  • Clone: REA940
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CR2, C3dR, CR, CVID7, SLEB9
  • Entrez Gene ID: 1380
  • Molecular mass of antigen [kDa]: 111
  • Cross-reactivity: cow, dog, pig
  • Distribution of antigen: B cells, dendritic cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Roberts, M. L. et al. (1996) Epstein—Barr virus binding to CD21, the virus receptor, activates resting B cells via an intracellular pathway that is linked to B cell infection. Virology 77: 3077-3085
    2. Braun, M. et al. (1998) Human B and T lymphocytes have similar amounts of CD21 mRNA, but differ in surface expression of the CD21 glycoprotein. Int. Immunol. 10: 1197-1202
    3. Cherukuri, A. et al. (2001) The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. J. Immunol. 167: 163-172
    4. Barrington, R. A. et al. (2005) CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J. Immunol. 175: 2589-2867
Product options: 10
130-115-609

CD21-FITC, human

for 30
tests
(1)
EUR 75.00
130-115-515

CD21-FITC, human

for 100
tests
(1)
EUR 185.00
130-115-610

CD21-PE, human

for 30
tests
(1)
EUR 90.00
130-115-516

CD21-PE, human

for 100
tests
(1)
EUR 220.00
130-115-611

CD21-APC, human

for 30
tests
(1)
EUR 90.00
130-115-517

CD21-APC, human

for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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