CD200 antibodies, human

CD200 antibodies, human

Clone: OX-104 | Dilution: 1:11
Clone OX-104 reacts with the human CD200 antigen, also known as MRC, MOX1/2, and OX-2, a type-1 membrane glycoprotein, which contains two immunoglobulin domains. Studies of the related gene in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. CD200 may serve as a cancer stem cell marker as co-expression with other reported stem cell markers was found on prostate, breast, brain, and colon cancers. In addition, CD200 expression was shown to be a prognostic factor in AML and multiple myeloma.

Alternative names

MOX1, Mox2, MRC, OX2, MOX1/2

Technical specifications

  • Antigen: CD200
  • Clone: OX-104
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: MOX1, Mox2, MRC, OX2, MOX1/2
  • Entrez Gene ID: 4345
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, mesenchymal stem cells, neurons, thymocytes, smooth muscle, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Moreaux, J. et al. (2007) CD200 as a prognostic factor in acute myeloid leukemia. Blood 108: 4194-4197
    2. Kawasaki, B. T. et al. (2007) Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells. Biochem. Biophys. Res. Commun. 364: 778-782
    3. Tonks, A. et al. (20007) CD200 as a prognostic factor in acute myeloid leukemia. Leukemia 21: 566-568
    4. Minas, K. et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit. Rev. Immunol. 26: 213-230
  • Brochures and posters

Product options: 5
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
130-096-819

CD200-PE, human

for 100
tests
(1)
EUR 220.00
130-096-816

CD200-APC, human

for 100
tests
(1)
EUR 220.00
for 100
tests
(1)
EUR 185.00

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