CD199 (CCR9) antibodies, human

CD199 (CCR9) antibodies, human

Clone: REA469 | Dilution: 1:11
Clone REA469 recognizes the human CD199 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 9 (CCR9) or G-protein coupled receptor 28 (GPR28). CD199 is a receptor for the chemokine thymus-expressed chemokine (TECK) and a member of the G protein coupled receptor family (GPCR). The main function of GPCR family members is to send signals into the cell after the activation of G-proteins and they are known for their roles in inflammation, leukocyte trafficking, and immune differentiation. CD199 subsequently transduces a signal by increasing the intracellular calcium ions level. It influences T cell development at several stages within the thymus. In peripheral blood, CD199 is expressed by naive CD8
+
T cells, but not by naive CD4
+
T cells. It is furthermore selectively expressed on plasmacytoid dendritic cells of immature phenotype
in vivo
. Different studies have shown the involvement of the CD199-TECK axis in colorectal, prostate, ovarian, and breast cancers.
Additional information: Clone REA469 displays negligible binding to Fc receptors.

Alternative names

CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28

Technical specifications

  • Antigen: CD199 (CCR9)
  • Clone: REA469
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28
  • Entrez Gene ID: 10803
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: dendritic cells, T cells, thymocytes, T helper cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Zaballos, A. et al. (1999) Cutting Edge: Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol. 162(10): 5671-5675
    2. Hadeiba, H. et al. (2008) CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat. Immunol. 9: 1253-1260
    3. Zhang, Z. et al. (2014) CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. Oncol. Rep. 31(4): 1629-1636
Product options: 12
for 30
tests
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EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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