CD170 (Siglec-5) antibodies, human

CD170 (Siglec-5) antibodies, human

Clone: REA1077 | Dilution: 1:50
Clone REA1077 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3- and α 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.
Additional information: Clone REA1077 displays negligible binding to Fc receptors.

Alternative names

CD33L2, OB-BP2, OBBP2, Siglec-5

Technical specifications

  • Antigen: CD170 (Siglec-5)
  • Clone: REA1077
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD33L2, OB-BP2, OBBP2, Siglec-5
  • Entrez Gene ID: 8778
  • Molecular mass of antigen [kDa]: 59
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    bonobo (
    Pan paniscus
    )
  • Distribution of antigen: dendritic cells, macrophages, monocytes, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
  • Selected references

    1. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
    2. Erickson-Miller, C. L. et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp. Hematol. 31(5): 382-388
    3. Avril, T. et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J. Biol. Chem. 280: 19843-19851
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EUR 300.00
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EUR 75.00
for 100
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EUR 185.00

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