CD161 antibodies, human

CD161 antibodies, human

Clone: 191B8 | Dilution: 1:50
Clone 191B8 recognizes CD161, a C-type lectin membrane glycoprotein. CD161, also known as NKR-P1A, is expressed as an 80 kDa disulfide-linked homodimer and is found on most NK cells and subsets of T cells. In peripheral blood, CD161 is preferentially expressed on T cells of memory phenotype, but it can also be found on subsets of thymocytes and fetal liver T cells.
CD161 has been implicated in triggering NK-mediated cytotoxicity, contributing to target cell recognition by NK cells.

Alternative names

KLRB1, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, HNKR-P1a

Technical specifications

  • Antigen: CD161
  • Clone: 191B8
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: KLRB1, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, HNKR-P1a
  • Entrez Gene ID: 3820
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: liver, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Lanier, L. L. et al. (1994) Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J. Immunol. 153: 2417-2428
    2. Poggi, A. et al. (2002)
      Transendothelial migratory pathways of Vδ1
      +
      TCRγδ
      +
      and Vδ2
      +
      TCRγδ
      +
      T lymphocytes from healthy donors and multiple sclerosis patients: involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II.
      J. Immunol. 168: 6071-6077
    3. Pozo, D. et al. (2006) CD161 (human NKRP1A) signaling in NK cells involves the activation of acid sphingomyelinase. J. Immunol. 176: 2397-2406
    4. Takahashi, T. et al. (2006) Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities.​ J. Immunol. 176: 211-216
Product options: 10
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00
130-114-119

CD161-PE, human

for 30
tests
(1)
EUR 90.00
130-113-593

CD161-PE, human

for 100
tests
(1)
EUR 220.00
130-114-116

CD161-APC, human

for 30
tests
(1)
EUR 90.00
130-113-590

CD161-APC, human

for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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