CD161 antibodies, human

CD161 antibodies, human

Clone: 191B8 | Dilution: 1:11
Clone 191B8 recognizes CD161, a C-type lectin membrane glycoprotein. CD161, also known as NKR-P1A, is expressed as an 80 kDa disulfide-linked homodimer and is found on most NK cells and subsets of T cells. In peripheral blood, CD161 is preferentially expressed on T cells of memory phenotype, but it can also be found on subsets of thymocytes and fetal liver T cells.
CD161 has been implicated in triggering NK-mediated cytotoxicity, contributing to target cell recognition by NK cells.

Alternative names

KLRB1, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, HNKR-P1a

Technical specifications

  • Antigen: CD161
  • Clone: 191B8
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: KLRB1, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, HNKR-P1a
  • Entrez Gene ID: 3820
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: liver, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure, PE-Vio770
  • Selected references

    1. Lanier, L. L. et al. (1994) Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J. Immunol. 153: 2417-2428
    2. Poggi, A. et al. (2002)
      Transendothelial migratory pathways of Vδ1
      +
      TCRγδ
      +
      and Vδ2
      +
      TCRγδ
      +
      T lymphocytes from healthy donors and multiple sclerosis patients: involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II.
      J. Immunol. 168: 6071-6077
    3. Takahashi, T. et al. (2006) Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities.​ J. Immunol. 176: 211-216
    4. Pozo, D. et al. (2006) CD161 (human NKRP1A) signaling in NK cells involves the activation of acid sphingomyelinase. J. Immunol. 176: 2397-2406
Product options: 1
100 µg in 1 mL
EUR 120.00