CD157 (BST-1) antibodies, human

CD157 (BST-1) antibodies, human

Clone: REA465 | Dilution: 1:11
Clone REA465 recognizes the human CD157 antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as bone marrow stromal antigen 1 (BST-1) or cyclic ADP-ribose hydrolase 2. CD157, a member of the CD38 gene family, is an NAD-metabolizing ectoenzyme and a signaling molecule, which synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, former a second messenger that elicits calcium release from intracellular stores. It is mainly expressed by cells of the myeloid lineage, bone marrow stroma, and vascular endothelium. CD157 is also expressed by ovarian cancer epithelium and by peritoneal mesothelial cells, where it is implicated in tumor dissemination. Further, it is endowed with receptor-like features observed in different cell types and transduces signals by interacting with transmembrane partner molecules, a strategy shared by other GPI-anchored molecules. CD157 is involved in neutrophil polarization, adhesion, and motility and controls transendothelial migration.
Additional information: Clone REA465 displays negligible binding to Fc receptors.

Alternative names

BST-1

Technical specifications

  • Antigen: CD157 (BST-1)
  • Clone: REA465
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: BST-1
  • Entrez Gene ID: 683
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: endothelial cells, granulocytes, bone marrow, stromal cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, APC-Vio770, Biotin, VioBright FITC, APC
  • Selected references

    1. Kaisho, T. et al. (1994) BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. U.S.A. 91(12): 5325-5329
    2. Ishihara, K. et al. (2000)
      BST-1/CD157 regulates the humoral immune responses
      in vivo
      .
      Chem. Immunol. 75: 235-255
    3. Morone, S. et al. (2014) Binding of CD157 protein to fibronectin regulates cell adhesion and spreading. J. Biol. Chem. 289(22): 15588-15601
Product options: 10
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00

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