Anti-MICA/MICB antibodies, human

Anti-MICA/MICB antibodies, human

Clone: REA1076 | Dilution: 1:50
Clone REA1076 recognizes MICA and MICB, which are transmembrane glycoproteins related to major histocompatibility complex (MHC) class I molecules. In contrast to other MHC class I proteins, MICA and MICB have no association with β2-microglobulin and do not bind peptides. They are ligands for NKG2D, which is expressed on NK cells and many T cells. MICA and MICB are expressed on endothelial cells and fibroblasts and are stress-induced in epithelial cells.
Additional information: Clone REA1076 displays negligible binding to Fc receptors.

Alternative names

MICB, PERB11.2, MICA, PERB11.1

Technical specifications

  • Antigen: MICA/MICB
  • Clone: REA1076
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MICB, PERB11.2, MICA, PERB11.1
  • Entrez Gene ID: 100507436, 4277
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: endothelial cells, epithelial cells, fibroblasts, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
    2. Bauer, S. et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729
    3. Li, P. et al. (1999) Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand. Immunity 10: 577-584
Product options: 14
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 125.00
for 100
tests
(1)
EUR 300.00
for 30
tests
(1)
EUR 75.00
for 100
tests
(1)
EUR 185.00