Anti-I-Aq antibodies, mouse

Anti-I-Aq antibodies, mouse

Clone: REA478 | Dilution: 1:10
Clone REA478 recognizes the mouse I-Aq MHC class II alloantigen. It also recognizes with I-As and I-Av.1. Reactivity with other haplotypes has not been reported. MHC (major histocompatibility complex) class II molecules are a family of molecules normally found on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. Because class II MHC is loaded with extracellular proteins, it is mainly concerned with presentation of extracellular pathogens.
Additional information: Clone REA478 displays negligible binding to Fc receptors.

Alternative names

MHC class II

Technical specifications

  • Antigen:
    I-A
    q
  • Clone: REA478
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: MHC class II
  • Entrez Gene ID: 14961
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, macrophages, monocytes, thymic epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Ishimaru, N. et al. (2018) CCL22-producing resident macrophages enhance T cell response in Sjögren's syndrome. Front Immunol 9: 2594
    2. Baumgart, M. et al. (1998) Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc. Natl. Acad. Sci. U.S.A. 95(12): 6936-6940
    3. Brand, D. D. et al. (2001) I-Aq and I-Ap bind and present similar antigenic peptides despite differing in their ability to mediate susceptibility to autoimmune arthritis. Autoimmunity 34(2): 133-145
    4. Bäcklund, J. et al. (2013) C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann. Rheum. Dis. 72(7): 1225-1232
Product options: 12
9 µg in 300 µL (1)
EUR 40.00
30 µg in 1 mL (1)
EUR 85.00
9 µg in 300 µL (1)
EUR 23.00
30 µg in 1 mL (1)
EUR 65.00
9 µg in 300 µL (1)
EUR 32.00
30 µg in 1 mL (1)
EUR 65.00
9 µg in 300 µL (1)
EUR 41.00
30 µg in 1 mL (1)
EUR 85.00
9 µg in 300 µL (1)
EUR 42.00
30 µg in 1 mL (1)
EUR 85.00
9 µg in 300 µL (1)
EUR 12.00
30 µg in 1 mL (1)
EUR 35.00

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