Anti-c-Cbl pY774 antibodies, human

Anti-c-Cbl pY774 antibodies, human

Clone: REA118 | Dilution: 1:11
Clone REA118 recognizes the Y774-phosphorylated form of human c-Cbl, which is a member of Cbl family of proteins. Cbl proteins serve as the negative regulators of antigen receptor signaling and contain N-terminal tyrosine kinase-binding (TKB) domain, which mediates binding to specific phosphotyrosine motifs on activated protein tyosine kinases (PTKs), a Zn-coordinating RING finger domain that interacts with ubiquitin-conjugating enzymes (E2s), a proline-rich region and a C-terminal leucine zipper-like region. c-Cbl unlike the other cbl proteins contains only a short proline-rich region and no C-terminal leucine zipper-like region. Cbl proteins acts as E3 ubiquitin ligase and tranfer ubiquitin molecules to tag activated receptors, PTKS, and signaling molecules for degradation.
Additional information: Clone REA118 displays negligible binding to Fc receptors.

Alternative names

CBL, CBL2, FRA11B, NSLL, RNF55

Technical specifications

  • Antigen: c-Cbl pY774
  • Clone: REA118
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CBL, CBL2, FRA11B, NSLL, RNF55
  • Entrez Gene ID: 867
  • Molecular mass of antigen [kDa]: 100
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected references

    1. Joazeiro, C. A. P. et al. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309
    2. Rao, N. et al. (2002) The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J. Leukoc. Biol. 71: 753-763
Product options: 8
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 90.00
for 100
tests
(1)
EUR 220.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00
for 30
tests
(1)
EUR 100.00
for 100
tests
(1)
EUR 240.00

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