Mouse IL-1β

Mouse IL-1β

IL-1β stands for interleukin 1β, also termed catabolin or IFN-β inducing factor. Mouse IL-1β is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-1β can be used for for a variety of applications including:
  • Activation of antigen-presenting cells
  • Polarization of TH 17 cells
  • Investigation of IL-1 receptor signaling

Alternative names

IL-1F2, Catabolin, MCF

Background information

Interleukin 1β (IL-1β) is a proinflammatory cytokine secreted mainly by monocytes and macrophages. IL-1β secretion has also been reported for a variety of other cells, including B cells, NK cells, dendritic cells, astrocytes, and microglial cells. It mediates inflammatory responses in B cells, T cells, and NK cells by inducing the production of cytokines, such as IL-2, IL-3, IL-6, as well as interferons. Upon exposure to IL-1β, endothelial cells and smooth muscle cells synthesize prostaglandins and other derivatives of arachidonic acid. In addition, during arthritic diseases, IL-1β causes degranulation of basophils and eosinophils as well as activation of osteoclasts. IL-1β is mitogenic for mesangial cells, glial cells, and keratinocytes.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
Premium-grade
cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).

Biological activity

  • Proliferation of D10.G4.1 cells (NIBSC 93/668)
  • premium grade: ≥ 8×
    10
    8
    U/mg
  • research grade: ≥ 5×
    10
    8
    U/mg
  • Selected references

    1. Vegran, F. et al. (2014) The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of Tʜ9 cells. Nat. Immunol. 15(8): 758-766
Product options: 6
E. coli
10 µg
EUR 149.00
E. coli
25 µg
EUR 280.00
E. coli
10 µg
EUR 184.00
E. coli
25 µg
EUR 350.00
E. coli
100 µg
EUR 815.00
E. coli
1000 µg
EUR 3,200.00