Clone:
REA834
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FLT4, Chy, FLT-4, VEGFR-3

Specifications for CD310 (VEGFR-3) Antibody, anti-mouse, REAfinity™

Overview

Clone REA843 recognizes the mouse CD310 antigen, a member of the receptor tyrosine kinase family. This 195 kDa molecule is also known as Flt-4 or VEGFR-3. During early embryogenesis all endothelial cells express CD310, while in the adult tissues CD310 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. CD310 expression is also induced upon tumor angiogenesis. VEGF-C and VEGF-D are ligands for CD310.
Additional information: Clone REA834 displays negligible binding to Fc receptors.

Alternative names

FLT4, Chy, FLT-4, VEGFR-3

Detailed product information

Technical specifications

CloneREA834
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD310 (VEGFR-3)
Alternative names of antigenFLT4, Chy, FLT-4, VEGFR-3
Molecular mass of antigen [kDa]151
Distribution of antigenendothelial cells, tumor cells
Entrez Gene ID14257
RRIDAB_2657331, AB_2657332, AB_2657333, AB_2657334, AB_2657335, AB_2657336, AB_2657337, AB_2657338, AB_2657339, AB_2657330

References for CD310 (VEGFR-3) Antibody, anti-mouse, REAfinity™

Publications

  1. Galland, F. et al. (1992) Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. Genomics 13(2): 475-478
  2. Kubo, H. et al. (2000) Involvement of vascular endothelial growth factor receptor-3 in maintance of integrity of endothelial cell lining during tumor angiogenesis. Blood 2(96): 546-553
  3. Zhang, L. et al. (2010) VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 20(12): 1319-1331

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