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The CliniMACS Prodigy® Hematopoietic Stem Cell Engineering (HSCE) process automates manufacturing of gene-engineered hematopoietic stem cells (HSCs) by viral transduction. Manufacturing takes place in sterile and single-use tubing sets connected to the CliniMACS Prodigy Instrument.

Request personal support or schedule an expert meeting to discuss how the CliniMACS Prodigy HSC Engineering process can simplify your research.

Benefits of the CliniMACS Prodigy HSC Engineering process at a glance


Ensuring standardized cell products over and over again


Robust performance reducing donor variations


Flexible software for easy conversion of your manual process

Functionally closed system

Reduced cleanroom requirements as well as increased product and operator safety

Overview of the CliniMACS Prodigy HSC Engineering workflow

CD34+ cells prepared in a cell bag are connected to the system and directly enter the automated HSC engineering process. Processing steps include cultivation, viral transduction, and harvesting of the gene-modified CD34+ cells. 

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