The CliniMACS Prodigy® Hematopoietic Stem Cell Engineering (HSCE) process automates manufacturing of gene-engineered hematopoietic stem cells (HSCs) by viral transduction. Manufacturing takes place in sterile and single-use tubing sets connected to the CliniMACS Prodigy Instrument.
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CD34+ cells prepared in a cell bag are connected to the system and directly enter the automated HSC engineering process. Processing steps include cultivation, viral transduction, and harvesting of the gene-modified CD34+ cells.