Clone:
REA903
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TGF beta Receptor II, TGFR-2, TbetaR-II

Specifications for TGF-β RII Antibody, anti-human, REAfinity™

Overview

Clone REA903 recognizes the human transforming growth receptor beta 2 (TGF-β RII) antigen, a single-pass transmembrane protein belonging to the superfamily of serine/threonine kinase receptors. Members of this family bind different TGF-β cytokines (TGF-β1, TGF-β2, TGF-β3) and other growth factors and cytokine signaling proteins. The association between TGF-β RII and TGF-β2 phosphorylates proteins, that regulate the transcription of a subset of genes related to cell proliferation in the nucleus.
Additional information: Clone REA903 displays negligible binding to Fc receptors.

Alternative names

TGF beta Receptor II, TGFR-2, TbetaR-II

Detailed product information

Technical specifications

CloneREA903
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTGF-β RII
Alternative names of antigenTGF beta Receptor II, TGFR-2, TbetaR-II
Molecular mass of antigen [kDa]62
Distribution of antigenmacrophages, other
Entrez Gene ID7048
RRIDAB_2726854, AB_2726889, AB_2726855, AB_2726890, AB_2726856, AB_2726887, AB_2726853, AB_2726888

References for TGF-β RII Antibody, anti-human, REAfinity™

Publications

  1. Doré, J. J. et al. (1998) Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells. J. Biol. Chem. 273(48): 31770-31777
  2. Rys, J. P. et al. (2015) Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension. Elife
  3. Narushima, Y. et al. (2016) Integrative network analysis combined with quantitative phosphoproteomics reveals transforming growth factor-beta receptor type-2 (TGFBR2) as a novel regulator of glioblastoma stem cell properties. Mol. Cell. Proteomics 15(3): 1017-1031

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