Clone:
HMN4-14
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC
Alternative names:
Int-3, Int3, N4

Specifications for Notch4 Antibody, anti-mouse

Overview

The HMN4-14 monoclonal antibody reacts with mouse Notch4, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multi-protein complex. Notch4 is preferentially expressed by endothelial cells, e.g., vascular smooth muscle cells and is reported to play a critical role in vasculogenesis and angiogenesis. It is also expressed on various other cell types including hematopetic cells. In addition, the altered expression of Notch4 by various leukemias, lymphomas, and cancers has been reported.

Alternative names

Int-3, Int3, N4

Detailed product information

Technical specifications

CloneHMN4-14
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenNotch4
Alternative names of antigenInt-3, Int3, N4
Molecular mass of antigen [kDa]204
Entrez Gene ID18132
RRIDAB_2653066, AB_2653067, AB_2653065

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