Clone:
MHN3-21
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
CADASIL, CASIL, IMF2, LMNS

Specifications for Notch3 Antibody, anti-human

Overview

The MHN3-21 monoclonal antibody reacts with the extracellular domain of human Notch3, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multi-protein complex. Notch3 is expressed on various various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. It can also be expressed on vascular smooth muscle and cells of the central nervous system. In addition, the altered expression of Notch3 by various leukemias, lymphomas, and cancers has been reported.

Alternative names

CADASIL, CASIL, IMF2, LMNS

Detailed product information

Technical specifications

CloneMHN3-21
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenNotch3
Alternative names of antigenCADASIL, CASIL, IMF2, LMNS
Molecular mass of antigen [kDa]240
Entrez Gene ID4854
RRIDAB_2653063, AB_2653064, AB_2653062

Resources for Notch3 Antibody, anti-human

Certificates

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Notch3 Antibody, anti-human

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