Mouse IL-33 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Mouse IL-33

Overview

Mouse IL-33 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-33 can be used for a variety of applications, including:
  • Tʜ2 cell activation and maintenance.
  • ILC activation.
  • Investigation of intracellular signaling of IL-1 family and apoptotic/necrotic pathways.

Detailed product information

Background information

IL-33 is expressed by several cell types including epithelial cells, endothelial cells, and fibroblasts, and binds a specific receptor, also known as IL1RL1, which is expressed on Tʜ2 cells and mast cells. Signaling via IL1RL1 involves receptor accessory protein (IL1RAP) and leads to the expression of type 2 cytokines, such as IL-4, IL-5, and IL-13. IL-33 is also expressed in blood epithelium and smooth muscle and plays a role in bone protection.

Biological activity

  • Proliferation of murine D10S cells.
  • research grade: ≥ 2×
    10
    6
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Mouse IL-33

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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