Alternative names:
IL-17

Specifications for Mouse IL-17A

Overview

IL-17A stands for interleukin 17A. Mouse IL-17A is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-17A can be used for a variety of applications, including:
  • Chemotactic assays.
  • Activation of macrophages and neutrophils.
  • In vitro models of inflammation and autoimmunity.

Alternative names

IL-17

Detailed product information

Background information

Interleukin 17A (IL-17A) is the founding member of the IL-17 family, which is composed of six members with different patterns of expression. The IL-17 family is characterized by a common disulfide-linked homodimeric structure, and different family members can also form heterodimers, such as IL-17A/IL-17F. IL-17 family members act as pro-inflammatory mediators involved in the immunity against extracellular pathogens, but they are extensively studied mainly for their pathogenic role in autoimmunity and allergy. T helper cells secrete IL-17A after polarization in Tʜ17 cells by specific cytokines such as TGF-β1, IL-6, IL-23, and IL-1β. Both IL-17A and IL-17F act on a specific receptor complex formed by IL-17RA and IL-17RC, expressed on different stromal cells in several tissues, such as endothelial cells, fibroblasts, and immune cells. IL-17A increases chemokine secretion by target cells and recruitment of monocytes and neutrophils. Secretion of IL-17A by Tʜ17 cells is common in several inflammatory and autoimmune diseases, such as rheumatoid arthritis, lupus, psoriasis, and multiple sclerosis. IL-17A also sustains angiogenesis and hematopoietic processes. Inhibitors of IL-17A are investigated as therapeutic tools in autoimmune disorders. Human and murine cells show partial cross-reactivity for corresponding homologous IL-17A.

Biological activity

  • IL-6 production by NIH3T3 cells

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Mouse IL-17A

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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