Clone:
NKM 16-2-4 
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2c
Applications:
FA, FC

Specifications for Microfold (M) Antibody, anti-mouse

Overview

Clone NKM 16-2-4 specifically binds (1,2)-fucose–containing carbohydrate moieties on murine microfold cells (M cells or membranous cells). Villous M cells are located in follicle-associated epithelium of Peyer’ s patches (PPs) and nasopharynx-associated lymphoid tissue (NALT). NKM 16-2-4 specifically binds to all subsets of M cells, but not epithelial cells or goblet cells located in PPs, NALT, and the intestinal villi in the gastrointestinal or respiratory tracts.
Microfold cells or membranous cells (M cells) have a high transcytotic activity and play an important role in the uptake of luminal antigens for induction of antigen-specific immune responses. This antibody (clone NKM 16-2-4) specifically binds to all subsets of M cells, but not epithelial cells or goblet cells located in Peyer's patches, nasopharynx-associated lymphoid tissue, and the intestinal villi in the gastrointestinal or respiratory tracts.

Detailed product information

Technical specifications

CloneNKM 16-2-4 
Clonalitymonoclonal
Isotyperat IgG2c
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenMicrofold (M)
RRIDAB_2660295, AB_2660296, AB_2660297, AB_2660313

References for Microfold (M) Antibody, anti-mouse

Publications

  1. Terahara, K. et al. (2008) Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J. Immunol. 180: 7840-846
  2. Kim, S-H. et al. (2010) The M cell-targeting ligand promotes antigen delivery and induces antigen-specific immune responses in mucosal vaccination. J. Immunol. 185: 5787-5795
  3. Kim, D-Y. et al. (2011) The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J. Immunol. 186: 4253-426
  4. Nochi, T. et al. (2007) A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J. Exp. Med. 204: 2789-2796

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