Clone:
REA457
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ITGA4, M290 IEL, Itga4B, Ly69, ITGB7, CD49d

Specifications for LPAM-1 Antibody, anti-mouse, REAfinity™

Overview

Clone REA457 recognizes the mouse Peyer’s patch adhesion molecule 1 (LPAM-1) antigen, a heterodimeric glycoprotein receptor, which is also known as α4β7 integrin. LPAM-1 is a cell surface adhesion molecule involved in lymphocyte trafficking and lymphocyte-cell and matrix interactions. It is expressed on T and B cells. Lymphocytes in spleen and mesenteric lymph nodes have low levels of LPAM-1 expression but can up-regulate their LPAM-1 expression on activation. Cellular ligands include vascular cell adhesion molecule 1 (VCAM-1) and the mucosal addressin cell adhesion molecule 1 (MAdCAM-1), which is present on high endothelial venules of mucosal lymphoid organs. Interaction of LPAM-1 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut.
Additional information: Clone REA457 displays negligible binding to Fc receptors.

Alternative names

ITGA4, M290 IEL, Itga4B, Ly69, ITGB7, CD49d

Detailed product information

Technical specifications

CloneREA457
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLPAM-1
Alternative names of antigenITGA4, M290 IEL, Itga4B, Ly69, ITGB7, CD49d
Molecular mass of antigen [kDa]197(sum of molecular weights of subunits)
Distribution of antigenB cells, T cells, lymphocytes
Entrez Gene ID16401, 16421
RRIDAB_2811535, AB_2811331

Resources for LPAM-1 Antibody, anti-mouse, REAfinity™

Certificates

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References for LPAM-1 Antibody, anti-mouse, REAfinity™

Publications

  1. Petrovic, A. et al. (2004) LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 103(4): 1542-1547
  2. Leung, E. et al. (1993) The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290. Int. Immunol. 5(5): 551-558
  3. Reese, S. R. et al. (2005) l-selectin and alpha4beta7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice. Surgery 137(2): 209-215

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