Clone:
REAL592
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
LMNA, LMN1, LMNL1, MADA, Prelamin-A/C, PRO1, CMD1A,, LGMD1B, Renal carcinoma antigen, NY-REN-32

Specifications for Lamin A/C Antibody, anti-human, REAdye_lease™

Overview

Clone REAL592 is an antibody fragment derived from the full Lamin A/C antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL592 recognizes Lamin A/C (Prelamin A/C), member of the lamin protein family, that are encoded by the LMNA gene. Lamin A and C are found in equal proportions in the lamina of mammals. Lamins are nuclear membrane structural components, that are thought to be involved in the regulation of the cell cycle, gene expression, nuclear stability, cell differentiation and apoptosis. Prelamin A/C can accelerate smooth muscle cell senescence by disrupting mitosis and induce DNA damage, leading to mitotic failure and genomic instability. Mutations in this gene lead to several diseases such as Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

LMNA, LMN1, LMNL1, MADA, Prelamin-A/C, PRO1, CMD1A,, LGMD1B, Renal carcinoma antigen, NY-REN-32

Detailed product information

Technical specifications

CloneREAL592
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitymouse, rat
AntigenLamin A/C
Alternative names of antigenLMNA, LMN1, LMNL1, MADA, Prelamin-A/C, PRO1, CMD1A,, LGMD1B, Renal carcinoma antigen, NY-REN-32
Distribution of antigenubiquitous, tonsil

Resources for Lamin A/C Antibody, anti-human, REAdye_lease™

Certificates

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References for Lamin A/C Antibody, anti-human, REAdye_lease™

Publications

  1. Gruenbaum, Y. et al. (2000) Review: nuclear lamins--structural proteins with fundamental functions. J Struct Biol. 129(2-3): 213-223
  2. Quijano-Roy, S. et al. (2008) De novo LMNA mutations cause a new form of congenital muscular dystrophy. Ann. Neurol. 64(2): 177-186
  3. Forleo, C. et al. (2015) Clinical and functional characterization of a novel mutation in lamin a/c gene in a multigenerational family with arrhythmogenic cardiac laminopathy. PLoS One 10(4): e0121723
  4. Messner, M. et al. (2918) Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. PLoS One 13(4): e0196739

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