Clone:
REA441
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
ITGB7, Ly69, M290 IEL

Specifications for Integrin β7 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA441 recognizes the human and mouse integrin β7 antigen, a single-pass type I membrane protein which is also known as gut homing receptor β subunit. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin β7 subfamily has two known members (α4β7 and αEβ7) that are expressed primarily by leukocytes and have been implicated in secondary lymphoid structure formation, plasma cells homing to gastrointestinal mucosa, and inflammatory responses. Their ligands: the mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) and E-cadherin are present on the surface of endothelial cells, bone marrow stromal cells, and epithelial cells. Interaction of α4β7 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut, whereas αEβ7 retains intraepithelial lymphocytes within the gut epithelium through E-cadherin binding. Integrin β7 is also reported to be involved in the pathogenesis of several diseases such as colitis, diabetic insulitis, and lymphoid malignancies including lymphomatous polyposis in mantle cell lymphoma, thymic lymphoma, and mucosa-associated T cell and B cell non-Hodgkin lymphomas.
Additional information: Clone REA441 displays negligible binding to Fc receptors.

Alternative names

ITGB7, Ly69, M290 IEL

Detailed product information

Technical specifications

CloneREA441
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenIntegrin β7
Alternative names of antigenITGB7, Ly69, M290 IEL
Molecular mass of antigen [kDa]86
Distribution of antigenleukocytes
Entrez Gene ID16421
RRIDAB_2751540, AB_2752017, AB_2751987, AB_2819501, AB_2819493, AB_2801890, AB_2652506, AB_2652507, AB_2652508, AB_2652509, AB_2751550

Resources for Integrin β7 Antibody, anti-human/mouse, REAfinity™

Certificates

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References for Integrin β7 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Alles, M. et al. (2014) Leukocyte β7 integrin targeted by Krüppel-like factors. J. Immunol. 193(4): 1737-1746
  2. Neri, P. et al. (2011) Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood 117(23): 6202-6213
  3. Hu, M. C. et al. (1992) Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Proc. Natl. Acad. Sci. U.S.A. 89(17): 8254-8258

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