Clone:
REA483
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA9B1, ITGA9, ITGA-RLC, ITGB1

Specifications for Integrin α9β1 Antibody, anti-human, REAfinity™

Overview

Clone REA483 recognizes the human integrin α9β1 antigen, a single-pass type I membrane protein which is also known as integrin alpha-RLC. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin α9β1 binds a number of extracellular matrix components like VCAM1, cytotactin, and osteopontin to mediate cell adhesion, migration, and tissue invasion. Although widely expressed in a variety of normal human cells including endothelium, different types of muscle cells, hepatocytes, and in the hematopoietic system, it is also expressed in cancer cells. Expression of integrin α9β1 in human cancers appears to correlate with higher grade tumors.
Additional information: Clone REA483 displays negligible binding to Fc receptors.

Alternative names

ITGA9B1, ITGA9, ITGA-RLC, ITGB1

Detailed product information

Technical specifications

CloneREA483
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, other
Cross-reactivityguinea pig
AntigenIntegrin α9β1
Alternative names of antigenITGA9B1, ITGA9, ITGA-RLC, ITGB1
Molecular mass of antigen [kDa]198(sum of molecular weights of subunits)
Distribution of antigenmonocytes, granulocytes, neutrophils, liver
Entrez Gene ID3680, 3688
RRIDAB_2652475, AB_2652476, AB_2652477, AB_2652478, AB_2652479, AB_2652474

Resources for Integrin α9β1 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Integrin α9β1 Antibody, anti-human, REAfinity™

Publications

  1. Kanayama, M. et al. (2011) α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Tʜ17 cell generation. J. Immunol. 187(11): 1271-1281
  2. Gupta, S. K. et al. (2013) Integrin α9β1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition. Oncogene 32(2): 141-150
  3. Ota, D. et al. (2014) Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. J. Mol. Med. 92(12): 1271-1281

Related products for
Integrin α9β1 Antibody, anti-human, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?