Clone:
REA1172
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL-1beta, IL-1B, IL1B, IL1F2

Specifications for IL-1β Antibody, anti-human, REAfinity™

Overview

Clone REA1172 recognizes the human IL-1β protein, a proinflammatory cytokine which belongs to the interleukin 1 (IL-1) family. IL-1β is primarly produced by macrophages, but also by monocytes and dendritic cells. It is secreted as a proprotein, that is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase/CASP1/ICE) to form mature IL-1β. It plays an essential role in inflammatory response, promotes cell differentiation, e.g. Tʜ17 differentiation of T cells, and is involved in other cellular activities, including apoptosis.
Additional information: Clone REA1172 displays negligible binding to Fc receptors.

Alternative names

IL-1beta, IL-1B, IL1B, IL1F2

Detailed product information

Technical specifications

CloneREA1172
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivitybaboon
AntigenIL-1β
Alternative names of antigenIL-1beta, IL-1B, IL1B, IL1F2
Molecular mass of antigen [kDa]17
Distribution of antigendendritic cells, macrophages, monocytes
Entrez Gene ID3553
RRIDAB_2801797, AB_2801801, AB_2801798, AB_2801802, AB_2801799, AB_2801800

References for IL-1β Antibody, anti-human, REAfinity™

Publications

  1. Van Damme, J. et al. (1985) Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature 314(6008): 266-268
  2. Zsebo, K .M. et al. (1988) Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood 71(4): 962-968
  3. Lukens, J. R. et al. (2014) Dietary modulation of the microbiome affects autoinflammatory disease. Nature 516(7530): 246-249

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