Clone:
REA285
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40

Specifications for IL-12 (p40/p70) Antibody, anti-mouse, REAfinity™

Overview

Clone REA285 recognizes both, the free and complexed forms (homodimer p80 and heterodimer p70) of the p40 subunit of interleukin-12 (IL-12) as well as of interleukin-23 (IL-23). IL-12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It acts as a growth factor for activated T and natural killer cells, and has a broad array of biological activities. IL-12 has been found to be important for sustaining a sufficient number of memory and effector Th1 cells to mediate long-term protection to intracellular pathogens. Overexpression of IL-12 was observed in the central nervous system of patients with multiple sclerosis, suggesting a role of IL-12 in the pathogenesis of the disease. IL-23, a heterodimeric cytokine which functions in innate and adaptive immunity, may constitute with IL-17 an acute response to infection in peripheral tissues. It stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. The REA285 antibody does not neutralize the bioactivity of natural or recombinant IL-12.
Additional information: Clone REA285 displays negligible binding to Fc receptors.

Alternative names

IL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40

Detailed product information

Technical specifications

CloneREA285
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-12 (p40/p70)
Alternative names of antigenIL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40
Molecular mass of antigen [kDa]36(sum of molecular weights of subunits)
Distribution of antigenmacrophages, T cells
Entrez Gene ID16160
RRIDAB_2652334, AB_2652335, AB_2652336, AB_2652333

Resources for IL-12 (p40/p70) Antibody, anti-mouse, REAfinity™

Certificates

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References for IL-12 (p40/p70) Antibody, anti-mouse, REAfinity™

Publications

  1. Oppmann, B. et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13(5): 715-725
  2. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146

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