Alternative names:
NTF-4

Specifications for Human NT-4

Overview

NT-4 stands for neurotrophin 4, also termed neurotrophin 5 (NT-5). Human NT-4 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human NT-4 may be used for a variety of applications, including:
  • Survival and differentiation of neuronal cell culture.
  • Investigation of Trk signaling.
  • Stimulation of axon outgrowth in vitro.

Alternative names

NTF-4

Detailed product information

Background information

Neurotrophin 4 (NT-4), also known as neurotrophin 5 (NT-5), is a member of the neurotrophin family. It shares high structural homology to nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3), but they all operate via different high-affinity membrane receptors and differ in target specificity. NT-4 is expressed in the prostate, thymus, placenta, as well as in skeletal muscles and signals predominantly through the TrkB tyrosine receptor kinase. NT-4 shows similar activities as NT-3 and is involved in the development and survival of neurons from the peripheral and central nervous system. Human NT-4 shares 91% amino acid sequence identity with mouse NT-4.

Biological activity

  • Induction of choline acetyl transferase activity
  • research grade: ≥ 2×
    10
    4
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human NT-4

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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