Clone:
REAL286
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
HLA-A, HLA-B, HLA-C, AS, SPDA1, D6S204, HLA-JY3, HLC-C, PSORS

Specifications for HLA-ABC Antibody, anti-human, REAdye_lease™

Overview

Clone REAL286 is an antibody fragment derived from the full HLA-ABC antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL286 recognizes a monomorphic epitope on MHC (human major histocompatibility complex) class I molecules, HLA A, B, and C. MHC class I molecules are expressed by all human nucleated cells and are involved in presentation of peptide ligands on the cell surface for recognition by cytotoxic T cells. HLA-ABC plays an deciding role in cell-mediated immune response and tumor surveillance.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

HLA-A, HLA-B, HLA-C, AS, SPDA1, D6S204, HLA-JY3, HLC-C, PSORS

Detailed product information

Technical specifications

CloneREAL286
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-ABC
Alternative names of antigenHLA-A, HLA-B, HLA-C, AS, SPDA1, D6S204, HLA-JY3, HLC-C, PSORS
Distribution of antigenubiquitous, lymph node
RRIDAB_2857549

Resources for HLA-ABC Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for HLA-ABC Antibody, anti-human, REAdye_lease™

Publications

  1. Melsted, W.N. et al. (2017) HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients. Clin. Immunol. 183: 191-197
  2. Chaganty, B. K. et al. (2015) Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion. Oncoimmunology 5(4): e1100790

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