Clone:
REA556
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
H60

Specifications for H60a Antibody, anti-mouse, REAfinity™

Overview

Clone REA556 recognizes the mouse H60a antigen, a histocompatibility antigen expressed in BALB but not C57BL/6 mouse strains. H60a is expressed on haematopoietic cells and is also is found on tumor cells that constitutively express H60a at the cell surface. H60a is recognized by H60a-specific CD8
+
T cells. H60a also binds natural killer group 2, member D (NKG2D) and can participate in tumor surveillance and cancer immunoediting. H60a is up-regulated by certain stimuli including DNA damage and virus infection.
Additional information: Clone REA556 displays negligible binding to Fc receptors.

Alternative names

H60

Detailed product information

Technical specifications

CloneREA556
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenH60a
Alternative names of antigenH60
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, dendritic cells, endothelial cells, granulocytes, macrophages, T cells, hematopoietic stem and progenitor cells
Entrez Gene ID15101
RRIDAB_2651974, AB_2651975, AB_2651976, AB_2651973

Resources for H60a Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for H60a Antibody, anti-mouse, REAfinity™

Publications

  1. Guerra, N. et al. (2008) NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 28(4): 571-580
  2. Yadav, D. et al. (2011) Studies on the antigenicity of the NKG2D ligand H60a in tumour cells. Immunology 133(2): 197-205
  3. Samarakoon, A. et al. (2009) Murine NKG2D ligands: "double, double toil and trouble". Mol. Immunol. 46(6): 1011-1019

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