Clone:
REA907
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
Enhancer of zeste homolog 2, KMT6

Specifications for EZH2 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA907 recognizes the human and mouse EZH2 protein, a methyltransferase which plays an essential role in the regulation of homeobox gene expression. EZH2, also known as enhancer of zeste homolog 2, belongs to the polycomp group (PcG). Members of this family play an essential role in stem-cell identity as well as cellular differentiation during development via transcriptional repression and disease. EZH2, first described in drosophila, is found in higher levels in different kind of tumor cells, and it is also expressed in thymocytes, and, depending on their stage, subsets of T cells and B cells.
Additional information: Clone REA907 displays negligible binding to Fc receptors.

Alternative names

Enhancer of zeste homolog 2, KMT6

Detailed product information

Technical specifications

CloneREA907
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivityrat, dog, chicken
AntigenEZH2
Alternative names of antigenEnhancer of zeste homolog 2, KMT6
Molecular mass of antigen [kDa]85(same molecular weight for human and mouse/rat)
Distribution of antigenB cells, T cells, tumor cells, B cell subsets, thymocytes
Entrez Gene ID14056, 2146
RRIDAB_2726937, AB_2726997, AB_2726938, AB_2726998, AB_2726939, AB_2726999, AB_2726940, AB_2726996

References for EZH2 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Chen, H. et al. (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38(1): 30-37
  2. Sauvageau, M. and Sauvageau, G. (2008) Polycomb group genes: keeping stem cell activity in balance. PLoS Biol. 6(4): e113
  3. Di Croce, L. et al. (2013) Transcriptional regulation by Polycomb group proteins. Nat. Struct. Mol. Biol. 20(10): 1147-1155

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