Clone:
REA1232
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
p185erbB2, HER2, MLN19, NEU, NGL, HER2/neu

Specifications for ErbB-2 (CD340) Antibody, anti-human, REAfinity™

Overview

Clone REA1232 recognizes the human receptor tyrosine-protein kinase ErbB-2 antigen, a Single-pass type I membrane protein which is also known as CD340, human epidermal growth factor receptor 2 (Her2) or proto-oncogene Neu. ErbB-2 is a member of the epidermal growth factor receptor family. The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. ErbB-2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. ErbB-2 has been shown to be involved in embryonic development and cancer progression. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of cancer. In recent years the protein has become an important biomarker and target of therapy for approx. 30% of breast cancer patients.
Additional information: Clone REA1232 displays negligible binding to Fc receptors.

Alternative names

p185erbB2, HER2, MLN19, NEU, NGL, HER2/neu

Detailed product information

Technical specifications

CloneREA1232
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenErbB-2 (CD340)
Alternative names of antigenp185erbB2, HER2, MLN19, NEU, NGL, HER2/neu
Molecular mass of antigen [kDa]136
Distribution of antigentumor cells
Entrez Gene ID2064
RRIDAB_2819625, AB_2819633, AB_2819626, AB_2819634, AB_2819627, AB_2819635, AB_2819628, AB_2819636, AB_2819629, AB_2819637, AB_2819630, AB_2819638, AB_2819631, AB_2819632

References for ErbB-2 (CD340) Antibody, anti-human, REAfinity™

Publications

  1. Yamamoto, T. et al. (1986) Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 319(6050): 230-234
  2. Wang, Y. N. et al. (2012) Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J. Biol. Chem. 287(20): 16869-16879
  3. Tsutsui, S. et al. (2002) Prognostic value of c-erbB2 expression in breast cancer. J Surg Oncol 79(4): 216-223

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