Clone:
REA475
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF25, Apo-3, DDR3, LARD, TR3, TRAMP, Tnfrsf12, WSL-1, DR3, WSL-1-like

Specifications for DR3 Antibody, anti-mouse, REAfinity™

Overview

Clone REA475 recognizes the mouse DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It is expressed primarily by CD4
+
and CD8
+
T and NKT cells. DR3 is also highly expressed by FoxP3 positive regulatory T lymphocytes. It mediates activation of NFκB and induces apoptosis. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation.
Additional information: Clone REA475 displays negligible binding to Fc receptors.

Alternative names

TNFRSF25, Apo-3, DDR3, LARD, TR3, TRAMP, Tnfrsf12, WSL-1, DR3, WSL-1-like

Detailed product information

Technical specifications

CloneREA475
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenDR3
Alternative names of antigenTNFRSF25, Apo-3, DDR3, LARD, TR3, TRAMP, Tnfrsf12, WSL-1, DR3, WSL-1-like
Molecular mass of antigen [kDa]44
Distribution of antigenT cells, T helper cells, NKT cells
Entrez Gene ID85030
RRIDAB_2651582, AB_2651583, AB_2651584, AB_2651581

Resources for DR3 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for DR3 Antibody, anti-mouse, REAfinity™

Publications

  1. Schreiber, T. H. et al. (2010) Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J. Clin. Invest. 120(10): 3629-3640
  2. Kitson, J. et al. (1996) A death-domain-containing receptor that mediates apoptosis. Nature 384(6607): 372-375
  3. Schreiber, T. H. et al. (2013) Immunobiology of TNFSF15 and TNFRSF25. Immunol. Res. 57(1-3): 3-11

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