Antigens for GMP-compliant in vitro stimulation of antigen-specific T cells

The MACS® GMP Antigen portfolio offers a large variety of peptide pools allowing rapid and consistent activation of antigen-specific T cells. MACS GMP Antigens are tailor-made for use with the CliniMACS® Cytokine Capture System (IFN-gamma), which enables the automated enrichment of virus- or tumor-specific T cells. Furthermore, they can also be employed for pulsing of dendritic cells to investigate vaccination approaches and for immunomonitoring.

MACS GMP PepTivator® Peptide Pools are synthesized high-purity products and are free of bacterial bioburden. Consistently high product quality is ensured by sterile filling according to Ph. Eur., lyophilization without carrier protein or preservatives, rigorous quality control, and an outstanding regulatory support.

MACS GMP Antigens are manufactured and tested under an ISO 13485 quality management system, in compliance with relevant GMP guidelines.

For complete regulatory notes click here.

How to isolate antigen-specific T cells for adoptive T cell therapy

CD4+ and CD8+ T cells stimulated in vitro with a specific antigen can be magnetically labeled with the CliniMACS Cytokine Capture System (IFN-gamma). In combination with the CliniMACS Prodigy® Instrument, the system allows fast and fully automated generation of antigen-specific T cells in a closed sterile system.

Further information on MACS GMP 

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A wide variety of automated cell processing applications are available for the CliniMACS Platforms. The separation of antigen-specific CD4+ and CD8+ T cells is just one of them.

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Fast and fully automated separation of antigen-specific T cells

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