Effective polyclonal T cell activation and expansion

Polyclonal activation and expansion of T cells serves to generate large numbers of effector cells and may be required to improve gene modification, for example, during cell manufacturing processes. Miltenyi Biotec’s nano-sized polymeric matrix T Cell TransAct™, soluble antibodies, and antibody-coated cell-sized particles (ExpAct™ Treg Kit) are well suited to achieve an effective polyclonal T cell stimulation and expansion in vitro. Conjugated to humanized recombinant CD3 and CD28 agonists, the nanomatrix MACS GMP T Cell TransAct can be sterile filtered and is tailor-made for the use in automated culture performed with the CliniMACS Prodigy® Instrument.

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Background information on GMP activation and expansion tools

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CAR T cell manufacturing on the CliniMACS Prodigy

Find out about the automated manufacture of CAR T cells in a closed system.

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