Clone:
REA1103
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
DHLAG, HLADG, II, Ia-GAMMA

Specifications for CD74 Antibody, anti-human, REAfinity™

Overview

Clone REA1103 recognizes CD74, a non-polymorphic type II integral membrane protein. CD74 is also known as MHC class II–associated invariant chain and exists in multiple isoforms in human ranging from 33 to 43 kDa in size. Initially known for its role as the MHC II chaperone, CD74 primary function is suggested to regulate the MHC class II molecules folding and intracellular sorting. CD74 is also shown to form complexes with CD182 (CXCR2) and CD184 (CXCR4). A direct role of CD74 in the maturation of follicular B cells and accumulation of marginal zone B cells has also been suggested. CD74 was further shown to be one of the host molecules utilized by
H. pylori
to successfully attach to the gastric epithelial cells. Expression of CD74 is found on B cells, dendritic cells, epithelial cells, subsets of activated T cells, and low level expression is found on monocytes and macrophages.
Additional information: Clone REA1103 displays negligible binding to Fc receptors.

Alternative names

DHLAG, HLADG, II, Ia-GAMMA

Detailed product information

Technical specifications

CloneREA1103
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD74
Alternative names of antigenDHLAG, HLADG, II, Ia-GAMMA
Molecular mass of antigen [kDa]33
Distribution of antigenB cells, dendritic cells, epithelial cells, macrophages, monocytes, T cells
Entrez Gene ID972
RRIDAB_2733403, AB_2733404, AB_2732984, AB_2732985, AB_2733248, AB_2733249, AB_2733143, AB_2733144, AB_2733041, AB_2733042, AB_2734027, AB_2734028, AB_2733534, AB_2733535, AB_2733836, AB_2733837

References for CD74 Antibody, anti-human, REAfinity™

Publications

  1. Leng, L. et al. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197: 1467-1476
  2. Beswick, E. J. and Reyes, V. E. (2009) CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. World J Gastroenterol. 15(23): 2855-2861

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