Clone:
REAL566
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
gp110, Lamp4, SCARD1, macrosialin

Specifications for CD68 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL566 is an antibody fragment derived from the full CD68 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL566 recognizes the human CD68 antigen, a 110 kDa type I transmembrane glycoprotein classified as a lysosomal/ endosomal-associated membrane glycoprotein (LAMP) family member. CD68 is highly expressed by human monocytes and tissue macrophages but also found in subpopulations of B cells, fibroblasts, endothelial, myeloid precursors, peripheral blood granulocytes, and plasmacytoid T cells. It is found predominantly in late endosomal and lysosomal compartments, with a modest level of cell surface expression. It is strongly expressed in chronic and acute myeloid leukemia but not in lymphomas. CD68 is suggested to be involved in phagocytic activities of tissue macrophages, in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

gp110, Lamp4, SCARD1, macrosialin

Detailed product information

Technical specifications

CloneREAL566
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD68
Alternative names of antigengp110, Lamp4, SCARD1, macrosialin
Distribution of antigenmonocytes, macrophages, B cells, fibroblasts, endothelial cells, other, B cell subsets, other, spleen
RRIDAB_2857592, AB_2857587

Resources for CD68 Antibody, anti-human, REAdye_lease™

Certificates

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References for CD68 Antibody, anti-human, REAdye_lease™

Publications

  1. Chao Ni et al. (2019) CD68- and CD163-positive tumor infiltrating macrophages in non-metastatic breast cancer: a retrospective study and meta-analysis. J Cancer 10(19): 4463-4472
  2. Saito, N. et al. (1991) Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes. Am. J. Pathol. 139: 1053-1059
  3. Holness, C. L. et al. (1993) Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J. Biol. Chem. 268: 9661-9666
  4. Holness, C. L. and Simmons, D. L. (1993) Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 81: 1607-1613
  5. Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108
  6. Gottfried, L. A. et al. (2008) Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. 67: 453-463

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